The CVS on E Street will close on May 6 after 65 years of operation, a company spokesperson confirmed Tuesday.

CVS spokesperson Amy Thibault said the E Street CVS will transfer all remaining merchandise and existing prescriptions to the 24-hour 2000 Pennsylvania Ave. location and offer employees “comparable roles” with the company. She said the company is closing the location for multiple reasons, including proximity to other CVS establishments and “local market dynamics.”

“We’ll continue to provide the community with outstanding service at our roughly 40 CVS Pharmacy locations in Washington, D.C.,” Thibault said in an email.

The E Street location’s closure comes as CVS, the largest retail pharmacy chain in the United States, continues a company-wide initiative to transition from retail sales toward health care services, which has resulted in hundreds of closures since 2022.

CVS Health, the parent company of CVS Pharmacy, merged with health insurance company Aetna in 2018 and began an initiative to close more than 900 stores between 2022 and 2024. In 2025, CVS announced plans to close 270 additional stores across the United States.

In August 2024, Metropolitan Police Department officers responded to a break-in at the E Street CVS after hours because suspects allegedly shattered the front glass door and destroyed an ATM.

Thibault said theft and crime were not factors in the store’s closing.

CVS permanently closed its location at 1901 Pennsylvania Ave. in December 2024, according to signs posted at the store. Both the notices at the 1901 Pennsylvania Ave. and E Street locations advised customers to use the 2000 Pennsylvania Ave. location inside Western Market as their primary store.

After these two closures, the 2000 Pennsylvania Ave. CVS will be the only location in Foggy Bottom.

The E Street location first opened in June 1960 as part of the now-defunct pharmacy chain Peoples Drug, which was based in Alexandria, Virginia and operated 490 stores in the Washington area. In 1990, Melville Corp. – which owned CVS at the time and has since merged with the company — purchased Peoples Drug, taking over all of its locations in D.C. and operating the E Street location since.

On April 7, the commercial real estate website Crexi listed the E Street location’s property as a “development site” for sale. The listing advertises the property for “repositioning” as condominiums, apartments or a hotel.

The listing on Crexi states the property’s current zoning classification means it “could likely be developed” into an approximately 67,000 square-foot building.

“Foggy Bottom has excellent demand for residential condominiums, apartments and hotel properties, which have sold in the immediate area for record prices in recent years,” the listing reads. “Additionally, due to the historic nature of the Foggy Bottom/GWU submarket, there are very few opportunities for redevelopment at all, let alone with scale.”